Biotechnology & Biotechnological Equipment (May 2016)

Identification of ESM-1 as a new endothelial biomarker in the pathogenesis of rheumatoid arthritis

  • Gönül Gürol Ciftci,
  • Ihsan Hakkı Ciftci,
  • Engin Karakece,
  • Halil Harman,
  • Ayhan Kamanlı,
  • Ibrahim Tekeoglu

DOI
https://doi.org/10.1080/13102818.2016.1148635
Journal volume & issue
Vol. 30, no. 3
pp. 548 – 552

Abstract

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The aim of this study was to investigate the use of ESM-1 (endothelial cell-specific molecule-1) as a new biomarker for the pathogenesis of rheumatoid arthritis (RA). The study cohort was divided into four groups according to the DAS28 disease activity score: 16 patients were classified as being in remission (DAS28 5.1); 20 healthy subjects were included as a control group. Serum samples were gathered from the patients with documented seropositivity for rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibodies in order to assess RF IgM and ESM-1. ESM-1 levels were significantly higher in patients with RA than in healthy subjects (p = 0.035). The data presented here strongly indicate ESM-1 as an attractive target for the treatment of inflammation-related diseases, such as RA.

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