Does the Daily Dose of Tadalafil for the Treatment of Erectile Dysfunction Increase Penile Sensation?

Abstract

Objective:To investigate the effect of tadalafil, used for treating erectile dysfunction (ED) at a daily dose of 5 mg for 12 weeks, on penile sensation.Materials and Methods:Our study included 30 male patients who applied to our andrology outpatient clinic with the complaint of ED and were prescribed tadalafil at a daily dose of 5 mg for 12 weeks. Before treatment, serum levels of testosterone and luteinizing hormone (LH) were measured. Demographic and clinical characteristics were recorded. Pre- and post-treatment electromyography (EMG) examinations for penile sensation and International Index of Erectile Function (IIEF-5) scoring were performed for each patient.Results:The mean age was 53±9 years. The mean body mass index was 27±2. Before treatment, serum levels of testosterone and LH were within the normal range. There were 8 (29%) patients with diabetes mellitus and 7 (25%) patients with hypertension. The pre- and post-treatment IIEF-5 scores were 13±3 and 19±3, respectively. Nerve conduction velocities (NCV) increased from 35.5 m/sec to 38.05 m/sec. Latency values decreased from 2.32 ms to 2.14 ms. There was a statistically significant improvement in IIEF-5 scores and EMG results for penile sensation after treatment (IIEF-5, NCV and latency; p<0.001, p<0.001 and p=0.001, respectively).Conclusion:In this study, we showed that tadalafil at a daily dose of 5 mg used for treating ED provides an increase in penile sensation.

Keywords

• erectile dysfunction
• oral phosphodiesterase-5 inhibitors
• penile sensation