Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small intestinal epithelia

Alaullah Sheikh; Brunda Tumala; Tim J. Vickers; John C. Martin; Bruce A. Rosa; Subrata Sabui; Supratim Basu; Rita D. Simoes; Makedonka Mitreva; Chad Storer; Erik Tyksen; Richard D. Head; Wandy Beatty; Hamid M. Said; James M. Fleckenstein

doi:10.1038/s41467-022-34687-7

Nature Communications (Nov 2022)

Enterotoxigenic Escherichia coli heat-labile toxin drives enteropathic changes in small intestinal epithelia

Alaullah Sheikh,
Brunda Tumala,
Tim J. Vickers,
John C. Martin,
Bruce A. Rosa,
Subrata Sabui,
Supratim Basu,
Rita D. Simoes,
Makedonka Mitreva,
Chad Storer,
Erik Tyksen,
Richard D. Head,
Wandy Beatty,
Hamid M. Said,
James M. Fleckenstein

Affiliations

Alaullah Sheikh: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine
Brunda Tumala: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine
Tim J. Vickers: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine
John C. Martin: The McDonnell Genome Institute, Washington University School of Medicine
Bruce A. Rosa: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine
Subrata Sabui: Departments of Medicine and Physiology/Biophysics, School of Medicine, University of California-Irvine
Supratim Basu: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine
Rita D. Simoes: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine
Makedonka Mitreva: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine
Chad Storer: The McDonnell Genome Institute, Washington University School of Medicine
Erik Tyksen: The McDonnell Genome Institute, Washington University School of Medicine
Richard D. Head: The McDonnell Genome Institute, Washington University School of Medicine
Wandy Beatty: Department of Molecular Microbiology, Washington University School of Medicine
Hamid M. Said: Departments of Medicine and Physiology/Biophysics, School of Medicine, University of California-Irvine
James M. Fleckenstein: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine

DOI: https://doi.org/10.1038/s41467-022-34687-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Enterotoxigenic Escherichia coli infections have been linked to non-diarrheal sequelae however, the reasons for this are unclear. Here, the authors present an additional role of heat-labile toxin in disrupting the structure and function of intestinal epithelial cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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