Polyketides and Alkaloids from the Marine-Derived Fungus Dichotomomyces cejpii F31-1 and the Antiviral Activity of Scequinadoline A against Dengue Virus
Dong-Lan Wu,
Hou-Jin Li,
Duncan R. Smith,
Janejira Jaratsittisin,
Xia-Fu-Kai-Ti Xia-Ke-Er,
Wen-Zhe Ma,
Yong-Wei Guo,
Jun Dong,
Juan Shen,
De-Po Yang,
Wen-Jian Lan
Affiliations
Dong-Lan Wu
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
Hou-Jin Li
School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China
Duncan R. Smith
Institute of Molecular Bioscience, Mahidol University, Bangkok 10700, Thailand
Janejira Jaratsittisin
Institute of Molecular Bioscience, Mahidol University, Bangkok 10700, Thailand
Xia-Fu-Kai-Ti Xia-Ke-Er
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
Wen-Zhe Ma
State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Avenida Wai Long, Taipa 519020, Macau, China
Yong-Wei Guo
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
Jun Dong
School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, China
Juan Shen
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
De-Po Yang
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
Wen-Jian Lan
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China
In our continuous chemical investigation on the marine-derived fungus Dichotomomyces cejpii F31-1, two new polyketides dichocetides B-C (1, 2), two new alkaloids dichotomocejs E-F (3, 4), and three known fumiquinozalines: scequinadoline A (5), quinadoline A (6), and scequinadoline E (7) were discovered from the culture broth and the mycelium in the culture medium, by the addition of l-tryptophan and l-phenylalanine. Their chemical structures were established by one dimensional (1D), two dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) data. Among them, scequinadoline A (5) exhibited significant inhibitory activity against dengue virus serotype 2 production by standard plaque assay, equivalent to the positive control andrographlide. Scequinadoline A (5) possesses the potential for further development as a dengue virus inhibitor.
