Inter-subject and inter-parcellation variability of resting-state whole-brain dynamical modeling
Oleksandr V. Popovych,
Kyesam Jung,
Thanos Manos,
Sandra Diaz-Pier,
Felix Hoffstaedter,
Jan Schreiber,
B.T. Thomas Yeo,
Simon B. Eickhoff
Affiliations
Oleksandr V. Popovych
Corresponding author at: Institute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany.; Institute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine, University Duesseldorf, Duesseldorf, Germany
Kyesam Jung
Institute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine, University Duesseldorf, Duesseldorf, Germany
Thanos Manos
Institute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine, University Duesseldorf, Duesseldorf, Germany; Laboratoire de Physique Théorique et Modélisation, CY Cergy Paris Université, CNRS, UMR 8089, Cergy-Pontoise cedex 95302, France
Sandra Diaz-Pier
Institute for Advanced Simulation, Juelich Supercomputing Centre (JSC), Research Centre Juelich, Juelich, Germany
Felix Hoffstaedter
Institute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine, University Duesseldorf, Duesseldorf, Germany
Jan Schreiber
Institute of Neuroscience and Medicine (INM-1), Research Centre Juelich, Juelich, Germany
B.T. Thomas Yeo
Centre for Sleep and Cognition, Centre for Translational MR Research & N.1 Institute for Health, National University of Singapore, Singapore; Department of Electrical and Computer Engineering, National University of Singapore, Singapore; Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, USA; Integrative Sciences and Engineering Programme (ISEP), Singapore
Simon B. Eickhoff
Institute of Neuroscience and Medicine (INM-7), Research Centre Juelich, Juelich, Germany; Institute of Systems Neuroscience, Medical Faculty, Heinrich-Heine, University Duesseldorf, Duesseldorf, Germany
Modern approaches to investigate complex brain dynamics suggest to represent the brain as a functional network of brain regions defined by a brain atlas, while edges represent the structural or functional connectivity among them. This approach is also utilized for mathematical modeling of the resting-state brain dynamics, where the applied brain parcellation plays an essential role in deriving the model network and governing the modeling results. There is however no consensus and empirical evidence on how a given brain atlas affects the model outcome, and the choice of parcellation is still rather arbitrary. Accordingly, we explore the impact of brain parcellation on inter-subject and inter-parcellation variability of model fitting to empirical data. Our objective is to provide a comprehensive empirical evidence of potential influences of parcellation choice on resting-state whole-brain dynamical modeling. We show that brain atlases strongly influence the quality of model validation and propose several variables calculated from empirical data to account for the observed variability. A few classes of such data variables can be distinguished depending on their inter-subject and inter-parcellation explanatory power.
