The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis

Qi Zhang; Rober Abdo; Cristiana Iosef; Tomonori Kaneko; Matthew Cecchini; Victor K. Han; Shawn Shun-Cheng Li

doi:10.1038/s41467-022-33365-y

Nature Communications (Oct 2022)

The spatial transcriptomic landscape of non-small cell lung cancer brain metastasis

Qi Zhang,
Rober Abdo,
Cristiana Iosef,
Tomonori Kaneko,
Matthew Cecchini,
Victor K. Han,
Shawn Shun-Cheng Li

Affiliations

Qi Zhang: Department of Pathology and Laboratory Medicine, Western University
Rober Abdo: Department of Pathology and Laboratory Medicine, Western University
Cristiana Iosef: Department of Biochemistry, Western University
Tomonori Kaneko: Department of Biochemistry, Western University
Matthew Cecchini: Department of Pathology and Laboratory Medicine, Western University
Victor K. Han: Children’s Health Research Institute
Shawn Shun-Cheng Li: Department of Biochemistry, Western University

DOI: https://doi.org/10.1038/s41467-022-33365-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 19

Abstract

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Brain metastases (BrMs) in non-small cell lung cancer (NSCLC) are associated with dismal outcomes, and are possibly sustained by the brain microenvironment. Here, the authors analyse NSCLC BrMs using Digital Spatial Profiling and reveal fibrosis, immune suppression, and cell reprogramming in the BrM microenvironment.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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