PLoS ONE (Jan 2016)

Comparative In Vivo Effects of Hemoglobin-Based Oxygen Carriers (HBOC) with Varying Prooxidant and Physiological Reactivity.

  • Vlad Al Toma,
  • Anca D Farcaș,
  • Ioana Roman,
  • Bogdan Sevastre,
  • Denisa Hathazi,
  • Florina Scurtu,
  • Grigore Damian,
  • Radu Silaghi-Dumitrescu

DOI
https://doi.org/10.1371/journal.pone.0153909
Journal volume & issue
Vol. 11, no. 4
p. e0153909

Abstract

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A series of hemoglobin-based oxygen carrier candidates (HBOC), previously noted for their differences in prooxidative and physiological reactivity, were compared in terms of the negative effects displayed upon injection in Wistar rats. At the concentrations tested, antioxidant strategies based on albumin as well as based on rubrerythrin appear to offer observable physiological advantages.