Osteopontin: Relation between Adipose Tissue and Bone Homeostasis

Carolina De Fusco; Antonietta Messina; Vincenzo Monda; Emanuela Viggiano; Fiorenzo Moscatelli; Anna Valenzano; Teresa Esposito; Chieffi Sergio; Giuseppe Cibelli; Marcellino Monda; Giovanni Messina

doi:10.1155/2017/4045238

Stem Cells International (Jan 2017)

Osteopontin: Relation between Adipose Tissue and Bone Homeostasis

Carolina De Fusco,
Antonietta Messina,
Vincenzo Monda,
Emanuela Viggiano,
Fiorenzo Moscatelli,
Anna Valenzano,
Teresa Esposito,
Chieffi Sergio,
Giuseppe Cibelli,
Marcellino Monda,
Giovanni Messina

Affiliations

Carolina De Fusco: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy
Antonietta Messina: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy
Vincenzo Monda: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy
Emanuela Viggiano: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy
Fiorenzo Moscatelli: Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy
Anna Valenzano: Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy
Teresa Esposito: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy
Chieffi Sergio: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy
Giuseppe Cibelli: Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy
Marcellino Monda: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy
Giovanni Messina: Department of Experimental Medicine, Section of Human Physiology and Unit of Dietetic and Sport Medicine, Second University of Naples, 16 Costantinopoli Str., 80138 Naples, Italy

DOI: https://doi.org/10.1155/2017/4045238
Journal volume & issue: Vol. 2017

Abstract

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Osteopontin (OPN) is a multifunctional protein mainly associated with bone metabolism and remodeling. Besides its physiological functions, OPN is implicated in the pathogenesis of a variety of disease states, such as obesity and osteoporosis. Importantly, during the last decades obesity and osteoporosis have become among the main threats to health worldwide. Because OPN is a protein principally expressed in cells with multifaceted effects on bone morphogenesis and remodeling and because it seems to be one of the most overexpressed genes in the adipose tissue of the obese contributing to osteoporosis, this mini review will highlight recent insights about relation between adipose tissue and bone homeostasis.

Published in Stem Cells International

ISSN: 1687-966X (Print); 1687-9678 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine
Website: https://www.hindawi.com/journals/sci/

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