Communications Biology (Aug 2022)
Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease
- Vasundara Srinivasan,
- Hévila Brognaro,
- Prince R. Prabhu,
- Edmarcia Elisa de Souza,
- Sebastian Günther,
- Patrick Y. A. Reinke,
- Thomas J. Lane,
- Helen Ginn,
- Huijong Han,
- Wiebke Ewert,
- Janina Sprenger,
- Faisal H. M. Koua,
- Sven Falke,
- Nadine Werner,
- Hina Andaleeb,
- Najeeb Ullah,
- Bruno Alves Franca,
- Mengying Wang,
- Angélica Luana C. Barra,
- Markus Perbandt,
- Martin Schwinzer,
- Christina Schmidt,
- Lea Brings,
- Kristina Lorenzen,
- Robin Schubert,
- Rafael Rahal Guaragna Machado,
- Erika Donizette Candido,
- Danielle Bruna Leal Oliveira,
- Edison Luiz Durigon,
- Stephan Niebling,
- Angelica Struve Garcia,
- Oleksandr Yefanov,
- Julia Lieske,
- Luca Gelisio,
- Martin Domaracky,
- Philipp Middendorf,
- Michael Groessler,
- Fabian Trost,
- Marina Galchenkova,
- Aida Rahmani Mashhour,
- Sofiane Saouane,
- Johanna Hakanpää,
- Markus Wolf,
- Maria Garcia Alai,
- Dusan Turk,
- Arwen R. Pearson,
- Henry N. Chapman,
- Winfried Hinrichs,
- Carsten Wrenger,
- Alke Meents,
- Christian Betzel
Affiliations
- Vasundara Srinivasan
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Hévila Brognaro
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Prince R. Prabhu
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Edmarcia Elisa de Souza
- Department of Parasitology, Institute of Biomedical Sciences at the University of São Paulo
- Sebastian Günther
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Patrick Y. A. Reinke
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Thomas J. Lane
- Hamburg Centre for Ultrafast Imaging (CUI), Universität Hamburg
- Helen Ginn
- Diamond Light Source Ltd. Diamond House, Harwell Science and Innovation Campus
- Huijong Han
- European XFEL GmbH. Holzkoppel 4
- Wiebke Ewert
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Janina Sprenger
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Faisal H. M. Koua
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Sven Falke
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Nadine Werner
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Hina Andaleeb
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Najeeb Ullah
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Bruno Alves Franca
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Mengying Wang
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Angélica Luana C. Barra
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Markus Perbandt
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Martin Schwinzer
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- Christina Schmidt
- European XFEL GmbH. Holzkoppel 4
- Lea Brings
- European XFEL GmbH. Holzkoppel 4
- Kristina Lorenzen
- European XFEL GmbH. Holzkoppel 4
- Robin Schubert
- European XFEL GmbH. Holzkoppel 4
- Rafael Rahal Guaragna Machado
- Department of Microbiology, Institute of Biomedical Sciences at the University of São Paulo
- Erika Donizette Candido
- Department of Microbiology, Institute of Biomedical Sciences at the University of São Paulo
- Danielle Bruna Leal Oliveira
- Department of Microbiology, Institute of Biomedical Sciences at the University of São Paulo
- Edison Luiz Durigon
- Department of Microbiology, Institute of Biomedical Sciences at the University of São Paulo
- Stephan Niebling
- European Molecular Biology Laboratory Hamburg, c/o DESY
- Angelica Struve Garcia
- European Molecular Biology Laboratory Hamburg, c/o DESY
- Oleksandr Yefanov
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Julia Lieske
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Luca Gelisio
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Martin Domaracky
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Philipp Middendorf
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Michael Groessler
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Fabian Trost
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Marina Galchenkova
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Aida Rahmani Mashhour
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Sofiane Saouane
- Photon Science, Deutsches Elektronen Synchrotron (DESY)
- Johanna Hakanpää
- Photon Science, Deutsches Elektronen Synchrotron (DESY)
- Markus Wolf
- Fraunhofer Institute for Translational Medicine and Pharmacology (ITMP)
- Maria Garcia Alai
- European Molecular Biology Laboratory Hamburg, c/o DESY
- Dusan Turk
- Department of Biochemistry & Molecular & Structural Biology, Jozef Stefan Institute
- Arwen R. Pearson
- Hamburg Centre for Ultrafast Imaging (CUI), Universität Hamburg
- Henry N. Chapman
- Hamburg Centre for Ultrafast Imaging (CUI), Universität Hamburg
- Winfried Hinrichs
- Institute of Biochemistry, Universität Greifswald
- Carsten Wrenger
- Department of Parasitology, Institute of Biomedical Sciences at the University of São Paulo
- Alke Meents
- Center for Free-Electron Laser Science, CFEL, Deutsches Elektronen Synchrotron DESY
- Christian Betzel
- Department of Chemistry, Institute of Biochemistry and Molecular Biology, Laboratory for Structural Biology of Infection and Inflammation, Universität Hamburg
- DOI
- https://doi.org/10.1038/s42003-022-03737-7
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 12
Abstract
Three natural phenolic compounds are found to bind to an allosteric site in SARS-CoV-2 papain-like protease and exhibit antiviral activity in vitro, showing potential as starting scaffolds for drug design.
