MODERN GENETIC ASPECTS OF PELVIC ORGAN PROLAPS

Abstract

The review of the russian and foreign literature on pelvic organ prolapse in women and its genetic aspects. According to the literature, an association of pelvic organ prolapse (POP) with a number of single nucleotide polymorphisms (SNPs) on chromosome 9q21, which are involved in the formation of elastic fibers of the connective tissue (CT). The association also polymorphism fibullin – 5 (FBLN5) and lysyl oxidase – like 1 (LOXL1) and theirrelationship to POP. Based on the literature, studies aimed at identifying the genetic nature of the POP, are incomplete and are important for the identification of risk groups who have a predisposition to POP, selecting the optimal policy for patients at risk and the initial stages of POP.

Keywords

• pelvic organ prolapse
• gene polymorphism fbln5
• loxl1
• snp 9q21