Frontiers in Oncology (Feb 2025)

A rare case of vision loss caused by leptomeningeal metastasis of lung adenocarcinoma: a case report and literature review

  • Zhihua Li,
  • Jian Chu,
  • Wennan Shen,
  • Junnan Chen,
  • Yuemei Dong,
  • Manze Zhang,
  • Nan Zhao,
  • Wei Zhao,
  • Haoran Zha,
  • Ning Wang,
  • Yalin Han,
  • Zhaoxia Li

DOI
https://doi.org/10.3389/fonc.2025.1484383
Journal volume & issue
Vol. 15

Abstract

Read online

Leptomeningeal metastasis (LM) is a fatal complication with increasing incidence in patients with non-small cell lung cancer. Herein, we present the case of a patient who presented with complete vision loss due to LM and achieved a survival benefit from treatment with trametinib. The treatment was prescribed based on the detection of a BRAF non-V600E mutation in the cerebrospinal fluid (CSF). We reviewed the literature and evaluated survival benefits in patients with LM harboring BRAF non-V600E mutations treated with CSF chemotherapy and mitogen-activated extracellular signal-regulated kinase inhibitors.

Keywords