Systematic comparison of experimental and human obstructive cholestasis reveals conservation of canonical pathway activation and biomarkers relevant for cholestatic liver disease

• Eva Gijbels,
• Kevin De Muynck,
• Bart Vanderborght,
• Tim Meese,
• Filip Van Nieuwerburgh,
• Aude Vanlander,
• Frederik Berrevoet,
• Bart Hendrikx,
• Anne Hoorens,
• Hans Van Vlierberghe,
• Mathieu Vinken,
• Lindsey Devisscher

Affiliations

Eva Gijbels

Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, 1090 Brussels, Belgium; Gut-Liver Immunopharmacology Unit, Basic and Applied Medical Sciences; Liver Research Centre Ghent; Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium

Kevin De Muynck

Gut-Liver Immunopharmacology Unit, Basic and Applied Medical Sciences; Liver Research Centre Ghent; Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium; Hepatology Research Unit, Internal Medicine and Paediatrics; Liver Research Centre Ghent; Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium

Bart Vanderborght

Hepatology Research Unit, Internal Medicine and Paediatrics; Liver Research Centre Ghent; Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium; Gut-Liver Immunopharmacology Unit, Basic and Applied Medical Sciences; Liver Research Centre Ghent; Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium

Tim Meese

Lab of Pharmaceutical Biotechnology, Ghent University, 9000 Ghent, Belgium; NXTGNT, Ghent University, 9000 Ghent, Belgium

Filip Van Nieuwerburgh

Lab of Pharmaceutical Biotechnology, Ghent University, 9000 Ghent, Belgium; NXTGNT, Ghent University, 9000 Ghent, Belgium

Aude Vanlander

Department of HPB Surgery and Liver Transplantation, Ghent University Hospital, 9000 Ghent, Belgium

Frederik Berrevoet

Department of HPB Surgery and Liver Transplantation, Ghent University Hospital, 9000 Ghent, Belgium

Bart Hendrikx

Department of HPB Surgery and Liver Transplantation, Ghent University Hospital, 9000 Ghent, Belgium

Anne Hoorens

Department of Pathology, Ghent University Hospital, 9000 Ghent, Belgium

Hans Van Vlierberghe

Hepatology Research Unit, Internal Medicine and Paediatrics; Liver Research Centre Ghent; Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium

Mathieu Vinken

Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, 1090 Brussels, Belgium

Lindsey Devisscher

Gut-Liver Immunopharmacology Unit, Basic and Applied Medical Sciences; Liver Research Centre Ghent; Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium; Corresponding author. Corneel Heymanslaan 10, building B, Entrance 36, 9000 Ghent, Belgium.