Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment

Gurpanna Saggu; Koshu Okubo; Yunfeng Chen; Ravi Vattepu; Naotake Tsuboi; Florencia Rosetti; Xavier Cullere; Nathaniel Washburn; Suhail Tahir; Aaron M. Rosado; Steven M. Holland; Robert M. Anthony; Mehmet Sen; Cheng Zhu; Tanya N. Mayadas

doi:10.1038/s41467-018-07506-1

Nature Communications (Nov 2018)

Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment

Gurpanna Saggu,
Koshu Okubo,
Yunfeng Chen,
Ravi Vattepu,
Naotake Tsuboi,
Florencia Rosetti,
Xavier Cullere,
Nathaniel Washburn,
Suhail Tahir,
Aaron M. Rosado,
Steven M. Holland,
Robert M. Anthony,
Mehmet Sen,
Cheng Zhu,
Tanya N. Mayadas

Affiliations

Gurpanna Saggu: Department of Pathology, Brigham and Women’s Hospital & Harvard Medical School
Koshu Okubo: Department of Pathology, Brigham and Women’s Hospital & Harvard Medical School
Yunfeng Chen: Institute for Bioengineering and Biosciences, Georgia Institute of Technology
Ravi Vattepu: Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital & Harvard Medical School
Naotake Tsuboi: Department of Pathology, Brigham and Women’s Hospital & Harvard Medical School
Florencia Rosetti: Department of Pathology, Brigham and Women’s Hospital & Harvard Medical School
Xavier Cullere: Department of Pathology, Brigham and Women’s Hospital & Harvard Medical School
Nathaniel Washburn: Momenta Pharmaceuticals
Suhail Tahir: Department of Pathology, Brigham and Women’s Hospital & Harvard Medical School
Aaron M. Rosado: Institute for Bioengineering and Biosciences, Georgia Institute of Technology
Steven M. Holland: National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Infectious Diseases, National Institutes of Health
Robert M. Anthony: Division of Rheumatology, Allergy and Immunology, Massachusetts General Hospital & Harvard Medical School
Mehmet Sen: Department of Biology and Biochemistry, University of Houston
Cheng Zhu: Institute for Bioengineering and Biosciences, Georgia Institute of Technology
Tanya N. Mayadas: Department of Pathology, Brigham and Women’s Hospital & Harvard Medical School

DOI: https://doi.org/10.1038/s41467-018-07506-1
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

Read online

Deposited immune complexes (IC) promote neutrophil recruitment, but the fine tuning of this process is still unclear. Here the authors show that the cis interaction of the IC receptor, FcγRIIA and CD18 integrin, Mac-1, on the neutrophil surface modulates neutrophil adhesion, with FcγRIIA sialylation specifically implicated in this interaction.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal