Hematological Parameters in Euthyroid and Hypothyroid Females

Abstract

Introduction: Thyroid hormone is an important metabolic hormone affecting hematological parameters. A variation in the hematological picture is seen in patients with hypothyroidism. Aims & Objectives: to study the differences in hematological parameters in hypothyroid and euthyroid females. Place and Duration of Study: A Comparative Cross-sectional study using secondary data was conducted from February 2022 to March 2023 at Muhammad Medical College, Pakistan. Material & Method: A total of 300 females (20-40 years of age, non-pregnant) were included in the study and based on their thyroid profile, they were divided into two groups, 160 with euthyroid status and another group of 140 with hypothyroidism. Hematological parameters were measured and compared in both groups. Data analysis was performed using Graph Pad Prism 9. A t-test, and one-way ANOVA were applied. The significance threshold is set at P < 0.05. Results: A significantly increased TSH and decreased T3 and T4 (p = < 0.05) were estimated in hypothyroid females. The hematological parameters in hypothyroid females showed hemoglobin (11.18± 1.66), ESR (32.70± 19.84), MCV (77.02± 6.84), MCH (24.00± 3.03), MHC (26.99± 3.67) and RDW (18.03± 4.56). The difference in hematological parameters between euthyroid and hypothyroid groups was found to be statistically significant with a P value of <0.001. Conclusion: Hypothyroidism showed a microcytic and hypochromic blood picture in females.

Keywords

• Thyroid dysfunction
• hypothyroidism
• hematological parameters
• blood composition
• thyroid hormone