Polish Journal of Microbiology (Aug 2016)

Search of the Antimicrobial Potential of Benzimidazole Derivatives

  • Monika Janeczko,
  • Zygmunt Kazimierczuk,
  • Andrzej Orzeszko,
  • Andrzej Niewiadomy,
  • Ewa Król,
  • Ryszard Szyszka,
  • Maciej Masłyk

DOI
https://doi.org/10.5604/17331331.1215615
Journal volume & issue
Vol. 65, no. 3

Abstract

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A broad series of 4,5,6,7-tetrahalogenated benzimidazoles and 4-(1H-benzimidazol-2-yl)-benzene-1,3-diol derivatives was tested against selected bacteria and fungi. For this study three plant pathogens Colletotrichum sp., Fusarium sp., and Sclerotinia sp., as well as Staphylo­coccus sp., Enterococcus sp., Escherichia sp., Enterobacter sp., Klebsiella spp. , and Candida spp. as human pathogens were used. MIC values and/or area of growth reduction method were applied in order to compare the activity of the synthesized compounds. From the presented set of 22 compounds, only 8, 16, 18 and 19 showed moderate to good inhibition against bacterial strains. Against Candida strains only compound 19 with three hydroxyl substituted benzene moiety presented high inhibition at nystatin level or lower.

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