Optimizing α-tricalcium phosphate bone cement composite formulations: The critical role of bioactive glass particle size

Abstract

Calcium phosphate cements (CPCs) have been extensively utilized as bone grafting material due to their inherent osteoconductive properties, although they often lacked sufficient biological performance for effective bone healing at the defect site. Incorporating mesoporous bioactive glass (MBG) into CPCs offers a solution by improving porosity, promoting degradation and increasing the available surface area. In the scope of this study, we integrated MBG into CPCs and assessed the impact of varying MBG particle sizes ( 92 % viability compared to control group). These findings underscore the critical impact of MBG particle size on developing advanced CPCs for biomedical applications, guiding future design and optimization strategies.

Keywords

• Calcium phosphate
• Bioactive glass
• Bone cements
• Mesoporous
• Bone regeneration
• Particle size