Nature Communications (Mar 2023)
Histone demethylase KDM2A is a selective vulnerability of cancers relying on alternative telomere maintenance
- Fei Li,
- Yizhe Wang,
- Inah Hwang,
- Ja-Young Jang,
- Libo Xu,
- Zhong Deng,
- Eun Young Yu,
- Yiming Cai,
- Caizhi Wu,
- Zhenbo Han,
- Yu-Han Huang,
- Xiangao Huang,
- Ling Zhang,
- Jun Yao,
- Neal F. Lue,
- Paul M. Lieberman,
- Haoqiang Ying,
- Jihye Paik,
- Hongwu Zheng
Affiliations
- Fei Li
- Department of Neurosurgery, Southwest Hospital
- Yizhe Wang
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Inah Hwang
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Ja-Young Jang
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Libo Xu
- Cold Spring Harbor Laboratory
- Zhong Deng
- The Wistar Institute
- Eun Young Yu
- Department of Microbiology and Immunology, W. R. Hearst Microbiology Research Center, Weill Cornell Medicine
- Yiming Cai
- Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center
- Caizhi Wu
- Cold Spring Harbor Laboratory
- Zhenbo Han
- Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center
- Yu-Han Huang
- Cold Spring Harbor Laboratory
- Xiangao Huang
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Ling Zhang
- Cold Spring Harbor Laboratory
- Jun Yao
- Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center
- Neal F. Lue
- Department of Microbiology and Immunology, W. R. Hearst Microbiology Research Center, Weill Cornell Medicine
- Paul M. Lieberman
- The Wistar Institute
- Haoqiang Ying
- Department of Molecular and Cellular Oncology, The University of Texas M. D. Anderson Cancer Center
- Jihye Paik
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- Hongwu Zheng
- Department of Pathology and Laboratory Medicine, Weill Cornell Medicine
- DOI
- https://doi.org/10.1038/s41467-023-37480-2
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 16
Abstract
Alternative lengthening of telomeres (ALT) provides cancer cells a mechanism to sustain replicative immortality. Here, the authors identify KDM2A as a molecular vulnerability in ALT-dependent cancer cells and demonstrate its role in the resolution of ALT-specific telomere clusters via recruitment of SENP6.
