Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae

Abstract

Microbial production of isoprene from renewable feedstock is a promising alternative to petroleum-based processes. Here, the authors show that isoprene production in the yeast Saccharomyces cerevisiaecan be improved by dual metabolic engineering of cytoplasmic and mitochondrial acetyl-CoA utilization.