Nature Communications (Apr 2019)

Influenza A virus ribonucleoproteins form liquid organelles at endoplasmic reticulum exit sites

  • Marta Alenquer,
  • Sílvia Vale-Costa,
  • Temitope Akhigbe Etibor,
  • Filipe Ferreira,
  • Ana Laura Sousa,
  • Maria João Amorim

DOI
https://doi.org/10.1038/s41467-019-09549-4
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 19

Abstract

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Influenza A virus forms cytosolic inclusions containing viral ribonucleoproteins. Here, the authors show that viral inclusions form juxtaposed the endoplasmic reticulum and have liquid properties, likely constituting sites of assembly of epidemic and pandemic influenza genomes.