Circular RNA in tumor metastasis

Chao Zhang; RongFang Ding; YiCheng Sun; Si Tong Huo; Alina He; Chang Wen; HongHao Chen; William W. Du; WeiNan Lai; Huijun Wang

Molecular Therapy: Nucleic Acids (Mar 2021)

Circular RNA in tumor metastasis

Chao Zhang,
RongFang Ding,
YiCheng Sun,
Si Tong Huo,
Alina He,
Chang Wen,
HongHao Chen,
William W. Du,
WeiNan Lai,
Huijun Wang

Affiliations

Chao Zhang: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, Guangdong Province, China; Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 510000, Guangdong Province, China; Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Corresponding author: Chao Zhang, Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, 705, Life Science Building, 1838 Guangzhou Boulevard, Guangzhou 510000, Guangdong Province, China.
RongFang Ding: Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou 510000, Guangdong Province, China
YiCheng Sun: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, Guangdong Province, China; Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 510000, Guangdong Province, China
Si Tong Huo: Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada; School of Medicine, Tsinghua University, Beijing 100084, China
Alina He: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada
Chang Wen: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, Guangdong Province, China; Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 510000, Guangdong Province, China
HongHao Chen: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Southern Medical University and Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Guangzhou 510000, Guangdong Province, China; Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 510000, Guangdong Province, China
William W. Du: Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON M4N 3M5, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON M5S 1A1, Canada
WeiNan Lai: Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China 510515; Correspondence; WeiNan Lai, Department of Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, Guangdong Province, China.
Huijun Wang: Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 510000, Guangdong Province, China; Corresponding author: Huijun Wang, Department of Laboratory Medicine, Nanhai Hospital, Southern Medical University, Foshan 510000, Guangdong Province, China.

Journal volume & issue: Vol. 23
pp. 1243 – 1257

Abstract

Read online

Circular RNAs (circRNAs) are a type of endogenous non-coding RNA that were discovered to regulate gene expression through multiple pathways. Metastasis remains one of the biggest obstacles in cancer treatment. In this review, we focus on circRNAs involved in cancer tumorigenesis and metastasis. We present recently identified tumor-related circRNAs and discuss their functioning in tumor progression and metastasis. These circRNAs are categorized into different functional mechanisms, including microRNA (miRNA) sponging, protein binding, regulation of host genes, translation of circRNAs, and exosomal circRNAs. Additionally, the indirect functions of circRNAs that regulate epithelial-mesenchymal transition and autophagy are also discussed.

Published in Molecular Therapy: Nucleic Acids

ISSN: 2162-2531 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.cell.com/molecular-therapy-family/nucleic-acids/latest-content

About the journal

Abstract

Keywords