U1 snRNP regulates cancer cell migration and invasion in vitro

Jung-Min Oh; Christopher C. Venters; Chao Di; Anna Maria Pinto; Lili Wan; Ihab Younis; Zhiqiang Cai; Chie Arai; Byung Ran So; Jingqi Duan; Gideon Dreyfuss

doi:10.1038/s41467-019-13993-7

Nature Communications (Jan 2020)

U1 snRNP regulates cancer cell migration and invasion in vitro

Jung-Min Oh,
Christopher C. Venters,
Chao Di,
Anna Maria Pinto,
Lili Wan,
Ihab Younis,
Zhiqiang Cai,
Chie Arai,
Byung Ran So,
Jingqi Duan,
Gideon Dreyfuss

Affiliations

Jung-Min Oh: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Christopher C. Venters: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Chao Di: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Anna Maria Pinto: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Lili Wan: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Ihab Younis: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Zhiqiang Cai: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Chie Arai: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Byung Ran So: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Jingqi Duan: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine
Gideon Dreyfuss: Howard Hughes Medical Institute, Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine

DOI: https://doi.org/10.1038/s41467-019-13993-7
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 8

Abstract

Read online

U1 snRNP is a key regulator of mRNA biogenesis through its roles in splicing, and transcription and 3’-end processing. Here the authors show a tumor suppressor-like function of U1 snRNP using in vitro cell migration/invasion assays and transcriptome profiling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal