Pencil‐Lead‐Based Quasi‐Equilibrium Glucose Biosensors

Abstract

Abstract Foreign body response is the main reason for the limited lifetime of implantable glucose biosensors. A new measurement strategy exerting minimal disturbance from the equilibrium glucose concentration in the sensor compartment has been proposed to mitigate its adverse effects on the sensor signal. Here, a new measurement strategy using automatically fabricated and robust pencil‐lead‐based glucose biosensors is implemented. The sensor response depends on critical parameters such as redox‐polymer film thickness, film uniformity, rigidity, polymer composition, and the ratio between the enzyme and the polymer. These parameters are controlled by introducing a short‐chain redox polymer, a low crosslinker amount, a short‐chain electrografting agent and linker, pulse electrografting, and an automated fabrication procedure.

Keywords

• FAD‐GDH
• glucose biosensors
• potentiometry
• pulse measurement