Data on specificity of [18F]GE180 uptake for TSPO expression in rodent brain and myocardium

Maximilian Deussing; Tanja Blume; Lena Vomacka; Christoph Mahler; Carola Focke; Andrei Todica; Marcus Unterrainer; Nathalie L. Albert; Simon Lindner; Barbara von Ungern-Sternberg; Karlheinz Baumann; Andreas Zwergal; Peter Bartenstein; Jochen Herms; Axel Rominger; Matthias Brendel

Data in Brief (Aug 2018)

Data on specificity of [18F]GE180 uptake for TSPO expression in rodent brain and myocardium

Maximilian Deussing,
Tanja Blume,
Lena Vomacka,
Christoph Mahler,
Carola Focke,
Andrei Todica,
Marcus Unterrainer,
Nathalie L. Albert,
Simon Lindner,
Barbara von Ungern-Sternberg,
Karlheinz Baumann,
Andreas Zwergal,
Peter Bartenstein,
Jochen Herms,
Axel Rominger,
Matthias Brendel

Affiliations

Maximilian Deussing: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany
Tanja Blume: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität München, Munich, Germany
Lena Vomacka: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany
Christoph Mahler: Inst. of Clinical Neuroimmunology, Ludwig-Maximilians-Universität München, Munich, Germany; Biomedical Center (BMC), Ludwig-Maximilians-Universität München, Munich, Germany
Carola Focke: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany
Andrei Todica: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany
Marcus Unterrainer: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany
Nathalie L. Albert: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany
Simon Lindner: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany
Barbara von Ungern-Sternberg: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany
Karlheinz Baumann: Roche Pharma Research and Early Development, Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland
Andreas Zwergal: Dept. of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany
Peter Bartenstein: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
Jochen Herms: Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität München, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany; Department of Translational Brain Research, DZNE - German Center for Neurodegenerative Diseases, Munich, Germany
Axel Rominger: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany
Matthias Brendel: Dept. of Nuclear Medicine, Ludwig-Maximilians-Universität München, Munich, Germany; Corresponding author.

Journal volume & issue: Vol. 19
pp. 331 – 336

Abstract

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Data in this article show radioligand uptake (to gamma counter and positron-emission-tomography) as well as polymerase chain reaction analyses of 18 kDa translocator protein (TSPO) quantification. We confirmed specificity of [18F]GE180 binding of rodent brain and myocardium by blocking experiments with prior application of non-radioactive GE180, using dynamic in vivo positron-emission-tomography and ex vivo gamma counter measurements. Expression of TSPO was compared between rodent brain and myocardium by quantitative polymerase chain reaction.

Published in Data in Brief

ISSN: 2352-3409 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Science: Science (General)
Website: http://www.journals.elsevier.com/data-in-brief/

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