Treatment data from the Brazilian fibromyalgia registry (EpiFibro)

Advances in Rheumatology. 2020;60(1):1-5 DOI 10.1186/s42358-019-0108-2


Journal Homepage

Journal Title: Advances in Rheumatology

ISSN: 2523-3106 (Online)

Publisher: BMC

Society/Institution: Brazilian Society of Rheumatology

LCC Subject Category: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the musculoskeletal system | Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Country of publisher: United Kingdom

Language of fulltext: English

Full-text formats available: PDF, HTML



Marcos Renato de Assis (Faculdade de Medicina de Marília (FAMEMA))

Eduardo dos Santos Paiva (Sociedade Brasileira de Reumatologia (SBR))

Milton Helfenstein (Sociedade Brasileira de Reumatologia (SBR))

Roberto Ezequiel Heymann (Sociedade Brasileira de Reumatologia (SBR))

Daniel Feldman Pollak (Sociedade Brasileira de Reumatologia (SBR))

Jose Roberto Provenza (Sociedade Brasileira de Reumatologia (SBR))

Aline Ranzolin (Sociedade Brasileira de Reumatologia (SBR))

Marcelo Cruz Rezende (Sociedade Brasileira de Reumatologia (SBR))

Luiz Severiano Ribeiro (Sociedade Brasileira de Reumatologia (SBR))

Eduardo José R. Souza (Sociedade Brasileira de Reumatologia (SBR))

José Eduardo Martinez (Sociedade Brasileira de Reumatologia (SBR))


Double blind peer review

Editorial Board

Instructions for authors

Time From Submission to Publication: 53 weeks


Abstract | Full Text

Abstract Background EpiFibro (Brazilian Epidemiological Study of Fibromyalgia) was created to study patients with fibromyalgia (FM). Patients were included since 2011 according to the classification criteria for FM of the American College of Rheumatology of 1990 (ACR1990). Objective To analyze the therapeutic measures prescribed by Brazilian physicians. Materials and methods Cross-sectional study of a multicenter cohort. The therapeutic measures were described using descriptive statistics. Results We analyzed 456 patients who had complete data in the registry. The mean age was 54.0 ± 11.9 years; 448 were women (98.2%). Almost all patients (98.4%) used medications, 62.7% received health education, and less than half reported practicing physical exercise; these modalities were often used in combination. Most patients who practiced exercises practiced aerobic exercise only, and a significant portion of patients combined it with flexibility exercises. The most commonly used medication was amitriptyline, followed by cyclobenzaprine, and a minority used medication specifically approved for FM, such as duloxetine and pregabalin, either alone or in combination. Combinations of two or three medications were observed, with the combination of fluoxetine and amitriptyline being the most frequent (18.8%). Conclusion In this evaluation of the care of patients with FM in Brazil, it was found that the majority of patients are treated with a combination of pharmacological measures. Non-pharmacological methods are underused, with aerobic exercise being the most commonly practiced exercise type. The most commonly prescribed single drug was amitriptyline, and the most commonly prescribed combination was fluoxetine and amitriptyline. Drugs specifically approved for FM are seldom prescribed.