Attenuation of Biochemical, Haematological and Histological Indices of Alloxan Toxicity in Male Rats by Aqueous Extract of Fadogia agrestis (Schweinf. Ex Hiern) Stem

Abstract

Background: The effects of aqueous extract of Fadogia agrestis stem at the doses of 18, 36, and 72 mg/kg body weight on alloxan-induced toxicity was investigated in Wistar rats. Methods: In total, 35 rats of both sexes (132.80±7.22g) were randomized into five groups (A-E): animals in group A received 0.5 ml of distilled water orally on daily basis for 15 days while the alloxanized rats in groups B, C, D and E also received orally 0.5 ml of distilled water and same volume of the extract corresponding to 18, 36, and 72 mg/kg body weight, respectively after which levels of some biomolecules were determined. Results: Administration of alloxan significantly (P0.05) with their respective non-alloxanized distilled water treated control animals in 78% of the parameters investigated. Conclusion: Overall, the aqueous extract of Fadogia agrestis stem attenuated the alloxan treatment related biochemical, haematological and histological changes in the rats with the 72 mg/kg body weight achieving total reversal in 18 out of the 23 parameters investigated.

Keywords

• Alloxan
• Diabetes Mellitus
• Fadogia agrestis
• Mitigation
• Reversal