Self-Powered Electrical Impulse Chemotherapy for Oral Squamous Cell Carcinoma

Chaochao Zhao; Yuan Yang; Xi Cui; Yizhu Shan; Jiangtao Xue; Dongjie Jiang; Jinyan Sun; Na Li; Zhou Li; Anping Yang

doi:10.3390/ma15062060

Materials (Mar 2022)

Self-Powered Electrical Impulse Chemotherapy for Oral Squamous Cell Carcinoma

Chaochao Zhao,
Yuan Yang,
Xi Cui,
Yizhu Shan,
Jiangtao Xue,
Dongjie Jiang,
Jinyan Sun,
Na Li,
Zhou Li,
Anping Yang

Affiliations

Chaochao Zhao: Department of Biomedical Engineering, School of Medicine, Foshan University, Foshan 528225, China
Yuan Yang: Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China
Xi Cui: Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China
Yizhu Shan: Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China
Jiangtao Xue: Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China
Dongjie Jiang: Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China
Jinyan Sun: Department of Biomedical Engineering, School of Medicine, Foshan University, Foshan 528225, China
Na Li: Department of Biomedical Engineering, School of Medicine, Foshan University, Foshan 528225, China
Zhou Li: Beijing Key Laboratory of Micro-Nano Energy and Sensor, Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, Beijing 101400, China
Anping Yang: Department of Biomedical Engineering, School of Medicine, Foshan University, Foshan 528225, China

DOI: https://doi.org/10.3390/ma15062060
Journal volume & issue: Vol. 15, no. 6
p. 2060

Abstract

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Oral squamous cell carcinoma (OSCC) is a common oral cancer of the head and neck, which causes tremendous physical and mental pain to people. Traditional chemotherapy usually results in drug resistance and side effects, affecting the therapy process. In this study, a self-powered electrical impulse chemotherapy (EIC) method based on a portable triboelectric nanogenerator (TENG) was established for OSCC therapy. A common chemotherapeutic drug, doxorubicin (DOX), was used in the experiment. The TENG designed with zigzag structure had a small size of 6 cm × 6 cm, which could controllably generate the fixed output of 200 V, 400 V and 600 V. The electrical impulses generated by the TENG increased the cell endocytosis of DOX remarkably. Besides, a simply and ingeniously designed microneedle electrode increased the intensity of electric field (EF) between two adjacent microneedle tips compared with the most used planar interdigital electrode at the same height, which was more suitable for three-dimensional (3D) cells or tissues. Based on the TENG, microneedle electrode and DOX, the self-powered EIC system demonstrated a maximal apoptotic cell ratio of 22.47% and a minimum relative 3D multicellular tumor sphere (MCTS) volume of 160% with the drug dosage of 1 μg mL−1.

Published in Materials

ISSN: 1996-1944 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Technology: Electrical engineering. Electronics. Nuclear engineering; Technology: Engineering (General). Civil engineering (General); Science: Natural history (General): Microscopy; Science: Physics: Descriptive and experimental mechanics
Website: http://www.mdpi.com/journal/materials/

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