Have nonsteroidal anti-inflammatory drugs a pathogenetic action?

Abstract

It is pointed out that there is weighty evidence that the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in osteoarthrosis (OA) and ankylosing spondyloarthritis (AS) can achieve not only symptomatic improvement, but also slower progression of the underlying pathological process. This effect is confirmed not only theoretically, but also experimentally and clinically. The information given in the review may serve as a ground for more active use of NSAIDs when there are direct indications for their use. It is stated that it is reasonable to switch from the purely symptomatic use of these drugs (only when pain occurs) to the practice of regular intake in their constant daily dose if pain in the joints and/or spine is present for most time.

Keywords

• nonsteroidal anti-inflammatory drugs
• pathogenetic action
• osteoarthrosis
• ankylosing spondyloarthritis