Journal of Cardio-Thoracic Medicine (Sep 2022)

Association of Serum Anti-Heat Shock Protein 27 Antibody with Obesity Risk among Healthy Individuals in MASHAD Study

  • Fatemeh Sadabadi,
  • Zahra Asadi,
  • Alireza Heidari Bakavoli,
  • Susan Darroudi,
  • Maryam Saberi-Karimian,
  • Saniya Saljoughian,
  • Maryam Shahi,
  • Mohammad Safarian,
  • Mohsen Nematy,
  • Gordon A. Ferns,
  • Majid Ghayour-Mobarhan,
  • Mohsen Mouhebati

DOI
https://doi.org/10.22038/jctm.2022.66266.1388
Journal volume & issue
Vol. 10, no. 3
pp. 1010 – 1016

Abstract

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Introduction: The association between the serum antibody titer of several heat shock proteins (HSPs) and cardiovascular disease (CVD) risk factors so far has been the subject of several previous studies.Aim: To evaluate the association of adiposity indices and HSP-27 antibody titers in healthy individuals.Materials and Methods: Overall 4823 individuals were recruited from Mashhad Stroke and Heart Atherosclerotic Disorders Study (MASHAD study), that included 1496 individuals with normal-weight (body mass index (BMI) <25 kg/m2), 1975 individuals with over-weight (BMI 25-30 kg/m2), and 1352 individuals with obesity (BMI≥ 30 kg/m2).Results: The serum anti-HSP-27 antibody titers were not significantly different among obese individuals [0.21 (0.11 – 0.34) absorbency unit (AU)], over-weight individuals [0.19 (0.10 – 0.33) AU] and normal-weight individuals [0.19 (0.10 – 0.33) AU].Conclusions: we have found no significant relationship among anti-HSP-27 antibody concentration and degrees of adiposity among Iranian adults.

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