Rumphellaoic Acid A, a Novel Sesquiterpenoid from the Formosan Gorgonian Coral Rumphella antipathies
Hsu-Ming Chung,
Wei-Hsien Wang,
Tsong-Long Hwang,
Lee-Shing Fang,
Zhi-Hong Wen,
Jih-Jung Chen,
Yang-Chang Wu,
Ping-Jyun Sung
Affiliations
Hsu-Ming Chung
Department of Applied Chemistry, National Pingtung University, Pingtung 900, Taiwan
Wei-Hsien Wang
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Tsong-Long Hwang
Graduate Institute of Natural Products, School of Traditional Medicine, College of Medicine, and Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan
Lee-Shing Fang
Department of Sport, Health and Leisure, Cheng Shiu University, Kaohsiung 833, Taiwan
Zhi-Hong Wen
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
Jih-Jung Chen
Department of Pharmacy, Tajen University, Pingtung 907, Taiwan
Yang-Chang Wu
School of Pharmacy, College of Pharmacy, China Medical University, Taichung 404, Taiwan
Ping-Jyun Sung
Department of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
A novel sesquiterpenoid, rumphellaoic acid A (1), was isolated from the gorgonian coral Rumphella antipathies, and was found to possess a carbon skeleton that was obtained for the first time from a natural sources. The structure of 1 was elucidated by spectroscopic methods and this compound and was found to exert a moderate inhibitory effect on the release of elastase by human neutrophils.
