Biomedicines (Oct 2024)

Serum Fatty Acids and Inflammatory Patterns in Severe Obesity: A Preliminary Investigation in Women

  • Gislene B. Lima,
  • Nayra Figueiredo,
  • Fabiana M. Kattah,
  • Emilly S. Oliveira,
  • Maria A. Horst,
  • Ana R. Dâmaso,
  • Lila M. Oyama,
  • Renata G. M. Whitton,
  • Gabriel I. M. H. de Souza,
  • Glaucia C. Lima,
  • João F. Mota,
  • Raquel M. S. Campos,
  • Flávia C. Corgosinho

DOI
https://doi.org/10.3390/biomedicines12102248
Journal volume & issue
Vol. 12, no. 10
p. 2248

Abstract

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Background: Inflammation plays a central role in many chronic diseases that characterize modern society. Leptin/adiponectin and adiponectin/leptin ratios have been recognized as notable markers of dysfunctional adipose tissue and, consequently, an inflammatory state. Methods: Blood samples were collected from 41 adult volunteers (40.2 ± 8.3 years) diagnosed with severe obesity (BMI 46.99; 42.98–51.91 kg/m2). The adipokines were quantified using an enzyme-linked immunosorbent assay, while the serum fatty acid analysis was conducted using chromatography. Results: The results unveiled a positive correlation between the leptin/adiponectin ratio and the 20:3n6 fatty acid (r = 0.52, p = 0.001), as well as a similar positive correlation between the adiponectin/leptin ratio and the 22:6n3 fatty acid (r = 0.74, p = 0.001). In the regression analysis, the 22:6n3 fatty acid predicted the adiponectin/leptin ratio (β = 0.76, p p Conclusions: In conclusion, the 22:6n3 fatty acid was demonstrated to be a predictive factor for the adiponectin/leptin ratio and C20:3 n-6 was a predictor for inflammatory markers. This discovery, novel within this population, can help develop new intervention strategies aimed at controlling the inflammatory status in individuals classified as having severe obesity.

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