Retinoblastoma genetics in India: From research to implementation

Abstract

Retinoblastoma is the prototypic genetic cancer. India carries the biggest burden of retinoblastoma globally, with an estimated 1500 new cases annually. Recent advances in retinoblastoma genetics are reviewed, focusing specifically on information with clinical significance to patients. The Indian literature on retinoblastoma clinical genetics is also highlighted, with a comment on challenges and future directions. The review concludes with recommendations to help clinicians implement and translate retinoblastoma genetics to their practice.

Keywords

• Intraocular
• lymphoma
• retina
• vitreous
• Conjunctiva
• cornea
• lymphoma
• melanoma
• ocular surface
• ocular surface squamous neoplasia
• tumor
• Brachytherapy
• chemotherapy
• cryopexy
• intra ocular tumors
• photocoagulation
• Animal uveitis model
• cytomegalovirus retinitis animal model
• endotoxin-induced uveitis
• experimental autoimmune uveitis
• spontaneous
• tubercular uveitis animal model
• India
• genetics
• retinoblastoma
• review