International Journal of General Medicine (Oct 2021)
Prognostic Value of Blood Urea Nitrogen to Serum Albumin Ratio in Intensive Care Unit Patients with Lung Cancer
Abstract
Xiulan Peng,1,* Yali Huang,1,* Haifeng Fu,2,* Zhi Zhang,3 Anbing He,1 Renfeng Luo4 1Department of Oncology, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei, People’s Republic of China; 2Department of Hepatopancreatobiliary Surgery, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Wuhan, Hubei, People’s Republic of China; 3Department of Intensive Care Unit, The Second Affiliated Hospital of Jianghan University, Wuhan, Hubei, People’s Republic of China; 4Department of Diagnostics, JiangHan University, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xiulan PengDepartment of Oncology, The Fifth Hospital of Wuhan, The Second Affiliated Hospital of Jianghan University, 122 Xianzheng Road, Wuhan, Hubei, 430050, People’s Republic of ChinaTel +86027-84830120Email [email protected]: We aimed to evaluate the prognostic ability of blood urea nitrogen (BUN) to serum albumin ratio (BAR) to predict in-hospital mortality in patients with lung cancer in the intensive care unit (ICU).Methods: Medical Information Mart for Intensive Care IV (MIMIC-IV v1.0) database was used to identify patients who were diagnosed with lung cancer. The primary outcome was in-hospital mortality. Multivariate COX regression was used to investigate the association between BAR and in-hospital mortality and propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) were also used to ensure the robustness of our findings. eICU-CRD database (validation cohort) was also applied to validate our findings.Results: The optimal cut-off value for BAR was 6.8mg/g. Among 1202 patients who were diagnosed with lung cancer, 287 high-BAR group (≥ 6.8mg/g) patients and 287 low-BAR group (< 6.8mg/g) patients, who had similar propensity scores were included in this study. After matching, the high-BAR group had significantly higher in-hospital mortality (hazard ratio, HR, 2.24, 95% confidence index, 95% CI, 1.57– 3.19, P< 0.001) even after adjustment for confounding factors. Moreover, the performance of BAR was superior to that of BUN and serum albumin alone and could add net benefit in predicting in-hospital mortality. Those results were further confirmed in the validation cohort.Conclusion: As an easily accessible and cost-effective parameter, BAR could serve as a good prognostic predictor for lung cancer patients in ICU.Keywords: blood urea nitrogen to serum albumin ratio, lung cancer, intensive care unit, Medical Information Mart for Intensive Care, eICU-CRD, prognosis
