Nature Communications (Feb 2020)

Discovering the genes mediating the interactions between chronic respiratory diseases in the human interactome

  • Enrico Maiorino,
  • Seung Han Baek,
  • Feng Guo,
  • Xiaobo Zhou,
  • Parul H. Kothari,
  • Edwin K. Silverman,
  • Albert-László Barabási,
  • Scott T. Weiss,
  • Benjamin A. Raby,
  • Amitabh Sharma

DOI
https://doi.org/10.1038/s41467-020-14600-w
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Complex diseases often share genetic determinants and symptoms, but the mechanistic basis of disease interactions remains elusive. Here, the authors propose a network topological measure to identify proteins linking complex diseases in the interactome, and identify mediators between COPD and asthma.