Nature Communications (Oct 2020)
Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity
- Felicity Newell,
- James S. Wilmott,
- Peter A. Johansson,
- Katia Nones,
- Venkateswar Addala,
- Pamela Mukhopadhyay,
- Natasa Broit,
- Carol M. Amato,
- Robert Van Gulick,
- Stephen H. Kazakoff,
- Ann-Marie Patch,
- Lambros T. Koufariotis,
- Vanessa Lakis,
- Conrad Leonard,
- Scott Wood,
- Oliver Holmes,
- Qinying Xu,
- Karl Lewis,
- Theresa Medina,
- Rene Gonzalez,
- Robyn P. M. Saw,
- Andrew J. Spillane,
- Jonathan R. Stretch,
- Robert V. Rawson,
- Peter M. Ferguson,
- Tristan J. Dodds,
- John F. Thompson,
- Georgina V. Long,
- Mitchell P. Levesque,
- William A. Robinson,
- John V. Pearson,
- Graham J. Mann,
- Richard A. Scolyer,
- Nicola Waddell,
- Nicholas K. Hayward
Affiliations
- Felicity Newell
- QIMR Berghofer Medical Research Institute
- James S. Wilmott
- Melanoma Institute Australia, The University of Sydney
- Peter A. Johansson
- QIMR Berghofer Medical Research Institute
- Katia Nones
- QIMR Berghofer Medical Research Institute
- Venkateswar Addala
- QIMR Berghofer Medical Research Institute
- Pamela Mukhopadhyay
- QIMR Berghofer Medical Research Institute
- Natasa Broit
- QIMR Berghofer Medical Research Institute
- Carol M. Amato
- Center for Rare Melanomas, University of Colorado Cancer Center, Aurora
- Robert Van Gulick
- Center for Rare Melanomas, University of Colorado Cancer Center, Aurora
- Stephen H. Kazakoff
- QIMR Berghofer Medical Research Institute
- Ann-Marie Patch
- QIMR Berghofer Medical Research Institute
- Lambros T. Koufariotis
- QIMR Berghofer Medical Research Institute
- Vanessa Lakis
- QIMR Berghofer Medical Research Institute
- Conrad Leonard
- QIMR Berghofer Medical Research Institute
- Scott Wood
- QIMR Berghofer Medical Research Institute
- Oliver Holmes
- QIMR Berghofer Medical Research Institute
- Qinying Xu
- QIMR Berghofer Medical Research Institute
- Karl Lewis
- Center for Rare Melanomas, University of Colorado Cancer Center, Aurora
- Theresa Medina
- Center for Rare Melanomas, University of Colorado Cancer Center, Aurora
- Rene Gonzalez
- Center for Rare Melanomas, University of Colorado Cancer Center, Aurora
- Robyn P. M. Saw
- Melanoma Institute Australia, The University of Sydney
- Andrew J. Spillane
- Melanoma Institute Australia, The University of Sydney
- Jonathan R. Stretch
- Melanoma Institute Australia, The University of Sydney
- Robert V. Rawson
- Melanoma Institute Australia, The University of Sydney
- Peter M. Ferguson
- Melanoma Institute Australia, The University of Sydney
- Tristan J. Dodds
- Melanoma Institute Australia, The University of Sydney
- John F. Thompson
- Melanoma Institute Australia, The University of Sydney
- Georgina V. Long
- Melanoma Institute Australia, The University of Sydney
- Mitchell P. Levesque
- Dermatology Clinic, University Hospital Zürich, University of Zurich
- William A. Robinson
- Center for Rare Melanomas, University of Colorado Cancer Center, Aurora
- John V. Pearson
- QIMR Berghofer Medical Research Institute
- Graham J. Mann
- Melanoma Institute Australia, The University of Sydney
- Richard A. Scolyer
- Melanoma Institute Australia, The University of Sydney
- Nicola Waddell
- QIMR Berghofer Medical Research Institute
- Nicholas K. Hayward
- QIMR Berghofer Medical Research Institute
- DOI
- https://doi.org/10.1038/s41467-020-18988-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Acral melanoma occurs on the soles of the feet, palms of the hands and in nail beds. Here, the authors reports the genomic landscape of 87 acral melanomas and find that some tumors harbor a UV signature and that the tumors are diverse at the levels of mutational signatures, structural aberrations and copy number signatures.
