Nature Communications (Jul 2018)
Integrative genomic analysis of adult mixed phenotype acute leukemia delineates lineage associated molecular subtypes
- Koichi Takahashi,
- Feng Wang,
- Kiyomi Morita,
- Yuanqing Yan,
- Peter Hu,
- Pei Zhao,
- Abdallah Abou Zhar,
- Chang Jiun Wu,
- Curtis Gumbs,
- Latasha Little,
- Samantha Tippen,
- Rebecca Thornton,
- Marcus Coyle,
- Marisela Mendoza,
- Erika Thompson,
- Jianhua Zhang,
- Courtney D. DiNardo,
- Nitin Jain,
- Farhad Ravandi,
- Jorge E. Cortes,
- Guillermo Garcia-Manero,
- Steven Kornblau,
- Michael Andreeff,
- Elias Jabbour,
- Carlos Bueso-Ramos,
- Akifumi Takaori-Kondo,
- Marina Konopleva,
- Keyur Patel,
- Hagop Kantarjian,
- P. Andrew Futreal
Affiliations
- Koichi Takahashi
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Feng Wang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Kiyomi Morita
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Yuanqing Yan
- Department of Biostatistics, The University of Texas MD Anderson Cancer Center
- Peter Hu
- Diagnostic Genetics Program, The University of Texas MD Anderson Cancer Center
- Pei Zhao
- Diagnostic Genetics Program, The University of Texas MD Anderson Cancer Center
- Abdallah Abou Zhar
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Chang Jiun Wu
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Curtis Gumbs
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Latasha Little
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Samantha Tippen
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Rebecca Thornton
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Marcus Coyle
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Marisela Mendoza
- Department of Genetics, The University of Texas MD Anderson Cancer Center
- Erika Thompson
- Department of Genetics, The University of Texas MD Anderson Cancer Center
- Jianhua Zhang
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Courtney D. DiNardo
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Nitin Jain
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Farhad Ravandi
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Jorge E. Cortes
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Guillermo Garcia-Manero
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Steven Kornblau
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Michael Andreeff
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Elias Jabbour
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Carlos Bueso-Ramos
- Department of Hematopathology, The University of Texas MD Anderson Cancer Center
- Akifumi Takaori-Kondo
- Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University
- Marina Konopleva
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- Keyur Patel
- Department of Hematopathology, The University of Texas MD Anderson Cancer Center
- Hagop Kantarjian
- Department of Leukemia, The University of Texas MD Anderson Cancer Center
- P. Andrew Futreal
- Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-018-04924-z
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Mixed phenotype acute leukemia (MPAL) is a rare leukemia that presents both myeloid and lymphoid markers on blasts. Here the authors perform genomic analysis to show MPAL involves genetic and epigenetic heterogeneity and is genetically distinct from AML, B-ALL, and T-ALL.
