Nature Communications (Mar 2022)
Antibody escape and global spread of SARS-CoV-2 lineage A.27
- Tamara Kaleta,
- Lisa Kern,
- Samuel Leandro Hong,
- Martin Hölzer,
- Georg Kochs,
- Julius Beer,
- Daniel Schnepf,
- Martin Schwemmle,
- Nena Bollen,
- Philipp Kolb,
- Magdalena Huber,
- Svenja Ulferts,
- Sebastian Weigang,
- Gytis Dudas,
- Alice Wittig,
- Lena Jaki,
- Abdou Padane,
- Adamou Lagare,
- Mounerou Salou,
- Egon Anderson Ozer,
- Ndodo Nnaemeka,
- John Kofi Odoom,
- Robert Rutayisire,
- Alia Benkahla,
- Chantal Akoua-Koffi,
- Abdoul-Salam Ouedraogo,
- Etienne Simon-Lorière,
- Vincent Enouf,
- Stefan Kröger,
- Sébastien Calvignac-Spencer,
- Guy Baele,
- Marcus Panning,
- Jonas Fuchs
Affiliations
- Tamara Kaleta
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Lisa Kern
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Samuel Leandro Hong
- Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- Martin Hölzer
- Methodology and Research Infrastructure, Bioinformatics, Robert Koch Institute
- Georg Kochs
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Julius Beer
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Daniel Schnepf
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Martin Schwemmle
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Nena Bollen
- Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- Philipp Kolb
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Magdalena Huber
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Svenja Ulferts
- Institute of Experimental and Clinical Pharmacology and Toxicology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Sebastian Weigang
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Gytis Dudas
- Gothenburg Global Biodiversity Centre
- Alice Wittig
- Methodology and Research Infrastructure, Bioinformatics, Robert Koch Institute
- Lena Jaki
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Abdou Padane
- Institut de Recherche en Santé, de Surveillance Epidémiologique et de Formation (IRESSEF)
- Adamou Lagare
- Centre de Recherche Médicale et Sanitaire (CERMES)
- Mounerou Salou
- Laboratoire de Biologie Moléculaire et d’Immunologie, Département des Sciences Fondamentales, Université de Lomé
- Egon Anderson Ozer
- Center for Pathogen Genomics and Microbial Evolution, Institute for Global Health, Northwestern University Feinberg School of Medicine
- Ndodo Nnaemeka
- National Reference Laboratory, Nigeria Centre for Disease Control
- John Kofi Odoom
- Department of Virology, Noguchi Memorial Institute for Medical Research, University of Ghana
- Robert Rutayisire
- Rwanda National Joint Task Force COVID-19, Rwanda Biomedical Centre, Ministry of Health
- Alia Benkahla
- Laboratory of BioInformatics bioMathematics, and bioStatistics (BIMS), Institut Pasteur de Tunis, University of Tunis El Manar
- Chantal Akoua-Koffi
- Laboratoire Central, Centre Hospitalier et Universitaire de Bouaké
- Abdoul-Salam Ouedraogo
- Department of Bacteriology and Virology, Souro Sanou University Hospital
- Etienne Simon-Lorière
- G5 Evolutionary Genomics of RNA Viruses, Department of Virology, Institut Pasteur
- Vincent Enouf
- National Reference Center for Respiratory Viruses, Institut Pasteur
- Stefan Kröger
- Department of Infectious Disease Epidemiology, Robert Koch Institute
- Sébastien Calvignac-Spencer
- Epidemiology of Highly Pathogenic Microorganisms, Robert Koch Institute
- Guy Baele
- Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven
- Marcus Panning
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- Jonas Fuchs
- Institute of Virology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg
- DOI
- https://doi.org/10.1038/s41467-022-28766-y
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
The A.27 SARS-CoV-2 lineage spread globally in 2021 but did not become dominant. Here, the authors show that A.27 shares some mutations in the spike gene that are present in variants of concern, but lacks the D614G mutation, indicating independent evolution of immune escape properties.
