Child Developmental MRI (CDM) project: protocol for a multi-centre, cross-sectional study on elucidating the pathophysiology of attention-deficit/hyperactivity disorder and autism spectrum disorder through a multi-dimensional approach
Tsuyoshi Sasaki,
Tetsuya Tsujikawa,
Hidehiko Okazawa,
Sayo Hamatani,
Yoshiyuki Hirano,
Eiji Shimizu,
Akemi Tomoda,
Koji Matsumoto,
Masatoshi Yamashita,
Yoshifumi Mizuno,
Kuriko Kagitani-Shimono,
Shota Nishitani,
Akiko Yao,
Sawa Kurata,
Hirotaka Kosaka,
Minyoung Jung,
Tokiko Yoshida,
Yoko Kato,
Mariko Nakanishi,
Masaya Tachibana,
Ikuko Mohri,
Kenji J Tsuchiya,
Masako Taniike
Affiliations
Tsuyoshi Sasaki
9 Department of Child Psychiatry and Psychiatry, Chiba University Hospital, Chiba, Japan
Tetsuya Tsujikawa
12 Department of Radiology, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
Hidehiko Okazawa
13 Biomedical Imaging Research Centre, University of Fukui, Fukui, Japan
Sayo Hamatani
1 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan
Yoshiyuki Hirano
4 Research Center for Child Mental Development, Chiba University, Chiba, Japan
Eiji Shimizu
1 Departments of Cognitive Behavioral Physiology, Chiba University Graduate School of Medicine School of Medicine, Chiba, Japan
Akemi Tomoda
1 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan
Koji Matsumoto
10 Department of Radiology, Chiba University Hospital, Chiba, Japan
Masatoshi Yamashita
1 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan
Yoshifumi Mizuno
1 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan
Kuriko Kagitani-Shimono
2 United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan
Shota Nishitani
1 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan
Akiko Yao
1 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan
Sawa Kurata
1 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan
Hirotaka Kosaka
1 Research Centre for Child Mental Development, University of Fukui, Fukui, Japan
Minyoung Jung
2 United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan
Tokiko Yoshida
5 Research Centre for Child Mental Development, Chiba University, Chiba, Japan
Yoko Kato
4 Department of Paediatrics, Osaka University Graduate School of Medicine, Osaka, Japan
Mariko Nakanishi
2 United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan
Masaya Tachibana
2 United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan
Ikuko Mohri
2 United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan
Kenji J Tsuchiya
2 United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan
Masako Taniike
2 United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Osaka, Japan
Introduction Neuroimaging studies on attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) have demonstrated differences in extensive brain structure, activity and network. However, there remains heterogeneity and inconsistency across these findings, presumably because of the diversity of the disorders themselves, small sample sizes, and site and parameter differences in MRI scanners, and their overall pathogenesis remains unclear. To address these gaps in the literature, we will apply the travelling-subject approach to correct site differences in MRI scanners and clarify brain structure and network characteristics of children with ADHD and ASD using large samples collected in a multi-centre collaboration. In addition, we will investigate the relationship between these characteristics and genetic, epigenetic, biochemical markers, and behavioural and psychological measures.Methods and analysis We will collect resting-state functional MRI (fMRI) and T1-weighted and diffusion-weighted MRI data from 15 healthy adults as travelling subjects and 300 children (ADHD, n=100; ASD, n=100; and typical development, n=100) with multi-dimensional assessments. We will also apply data from more than 1000 samples acquired in our previous neuroimaging studies on ADHD and ASD.Ethics and dissemination The study protocol has been approved by the Research Ethics Committee of the University of Fukui Hospital (approval no: 20220601). Our study findings will be submitted to scientific peer-reviewed journals and conferences.
