Nature Communications (Oct 2019)

Structural transitions during the scaffolding-driven assembly of a viral capsid

  • Athanasios Ignatiou,
  • Sandrine Brasilès,
  • Mehdi El Sadek Fadel,
  • Jörg Bürger,
  • Thorsten Mielke,
  • Maya Topf,
  • Paulo Tavares,
  • Elena V. Orlova

DOI
https://doi.org/10.1038/s41467-019-12790-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 11

Abstract

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Viral assembly is a complex process that in tailed bacteriophages involves scaffolding proteins which coordinate assembly of the phage procapsid and are subsequently released during maturation. Here the authors reveal the conformational changes that accompany virion maturation, documenting how the dissociation of scaffold proteins and DNA packaging processes intersect.