Acta Biomedica Scientifica (Jul 2013)
THE STATE OF LIPID PEROXIDATION PROCESSES IN INFERTILE WOMEN WITH HYPERPROLACTINEMIA
Abstract
Infertility is a problem of medicine with a large magnitude. It is believed that oxidative stress (OS) modulates the age-related decline in fertility. OS can arise as result of excessive production of free radicals and/or impaired antioxidant defense mechanism. Lipid state and «lipid peroxidation antioxidant protection» system were studied in 60 women with infertility and hyperprolactinemia The materialsfor biochemical studies were blood serum and red cells. Lipid components were evaluated by a automatic analyzer Cormay «BTS-330» with photometry method. The content of the substrates and products of lipid peroxidation (diene conjugates, ketodienes and coupled trienes, malondialdehyde), total antioxidant activity of serum and its components (superoxide dismutase, α-tocopherol, retinol, reduced and oxidized glutathione) were evaluated by a spektroflyuorofotometr «SHIMADZU-1501» (Japan). The concentration of prolactin was evaluated by a set of «Diaz» (Russia) and analyzer «Immunotest». Statisical analysis was performed by non-parametric tests. In women with infertility and hyperprolactinemia increase ofconcentraion of atherogenic and decrease of antiatherogenic lipoproteins and triglycerides takes place. In addition, atherogenic factor increases. It has been established that in evaluated infertile patients lipid peroxidation processes were excessed, while the level of output (TBA-active) products was reducing. Antioxidant protecion state in hyperprolacinemia and infertility is characterized by reduced levels of fatand water-soluble vitamins, increasing total antioxidant activity, an imbalance in the glutathione system. The study was supported by grants of President ofthe Council ofthe Russian Federation (Scientific School 494.2012.7).
