Heterogenety of macrophages reaction during foot wounds healing in diabetic patients

Abstract

To establish the role of macrophages in diabetic foot syndrome pathogenesis the morphometric analysis of space-time distribution of CD68+ cells was performed in skin bioptates in diabetic patients with wound healing during 24 days (1 group; n=18), non-healing wounds (more than 1,5 month – 2 group, n=12), and progressive destructive process (3 group, n=15). It was shown that changes in macrophages reaction is important factor in dysregeneration syndrome in diabetic foot pathogenesis. Hyperreaction of macrophages was accompanied with prolongation of wound healing, but anergy of macro-phageal system led to alteration of inflammatory reaction limiting and progress of destructive process.

Keywords

• diabetic foot syndrome
• dysregeneration syndrome
• macrophageal system