Nature Communications (Dec 2017)
The LPS-inducible lncRNA Mirt2 is a negative regulator of inflammation
- Meng Du,
- Lin Yuan,
- Xin Tan,
- Dandan Huang,
- Xiaojing Wang,
- Zhe Zheng,
- Xiaoxiang Mao,
- Xiangrao Li,
- Liu Yang,
- Kun Huang,
- Fengxiao Zhang,
- Yan Wang,
- Xi Luo,
- Dan Huang,
- Kai Huang
Affiliations
- Meng Du
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Lin Yuan
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xin Tan
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Dandan Huang
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xiaojing Wang
- Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Zhe Zheng
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xiaoxiang Mao
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xiangrao Li
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Liu Yang
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Kun Huang
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Fengxiao Zhang
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Yan Wang
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Xi Luo
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Dan Huang
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- Kai Huang
- Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
- DOI
- https://doi.org/10.1038/s41467-017-02229-1
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 18
Abstract
Excessive inflammation can be tissue destructive and contributes to auotinflammatory diseases and sepsis pathology. Here the authors show that the lncRNA Mirt2 is an endogenous negative feedback regulator of LPS-induced inflammation by limiting ubiquitination of TRAF6 and NF-κB activation.
