Comorbid medical illness as a predisposing factor for the treatment-resistant depression. Part 1: Mechanisms of treatment resistance

Abstract

Management of treatment-resistant depression is one of the most important problems in modern psychiatry. Comorbidity of depression with medical diseases is one of the predisposing factors for the development of treatment resistance due to various mechanisms, including genetic, endocrine, neuroimmune, pharmacogenic, psychosocial, etc. Along with the efforts to reduce the negative effects of the above-mentioned mechanisms (limited by currently available therapeutic options), optimization of antidepressant treatment with regards to existing comorbid medical problems is important for prevention of treatment resistance development.

Keywords

• терапевтически резистентная депрессия
• коморбидность
• соматические заболевания
• механизмы формирования резистентности
• treatment-resistant depression
• comorbidity
• medical illness
• mechanisms of treatment resistance