Thermosensitive hydrogel releasing nitric oxide donor and anti-CTLA-4 micelles for anti-tumor immunotherapy

Jihoon Kim; David M. Francis; Lauren F. Sestito; Paul A. Archer; Margaret P. Manspeaker; Meghan J. O’Melia; Susan N. Thomas

doi:10.1038/s41467-022-29121-x

Nature Communications (Mar 2022)

Thermosensitive hydrogel releasing nitric oxide donor and anti-CTLA-4 micelles for anti-tumor immunotherapy

Jihoon Kim,
David M. Francis,
Lauren F. Sestito,
Paul A. Archer,
Margaret P. Manspeaker,
Meghan J. O’Melia,
Susan N. Thomas

Affiliations

Jihoon Kim: Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
David M. Francis: Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Lauren F. Sestito: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
Paul A. Archer: Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Margaret P. Manspeaker: Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology
Meghan J. O’Melia: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology
Susan N. Thomas: Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology

DOI: https://doi.org/10.1038/s41467-022-29121-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Nitric oxide exerts a multitude of physiological functions and has also been exploited for anticancer therapies. Here the authors report the design of a micelle-releasing thermosensitive hydrogel system for the concomitant locoregional and lymphatic delivery of a nitric oxide donor and an anti-CTLA4 antibody, showing anti-tumor immune responses in preclinical cancer models.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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