Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche

Akshay Patel; Yicong Wu; Xiaofei Han; Yijun Su; Tim Maugel; Hari Shroff; Sougata Roy

doi:10.1038/s41467-022-28587-z

Nature Communications (Mar 2022)

Cytonemes coordinate asymmetric signaling and organization in the Drosophila muscle progenitor niche

Akshay Patel,
Yicong Wu,
Xiaofei Han,
Yijun Su,
Tim Maugel,
Hari Shroff,
Sougata Roy

Affiliations

Akshay Patel: Department of Cell Biology and Molecular Genetics, University of Maryland
Yicong Wu: Laboratory of High-Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Xiaofei Han: Laboratory of High-Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Yijun Su: Laboratory of High-Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Tim Maugel: Department of Biology, Laboratory for Biological Ultrastructure, University of Maryland
Hari Shroff: Laboratory of High-Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
Sougata Roy: Department of Cell Biology and Molecular Genetics, University of Maryland

DOI: https://doi.org/10.1038/s41467-022-28587-z
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

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Asymmetric signaling and organization in the stem cell niche determine cell fates. Here the authors show that polarized contact-dependent signaling through specialized cytonemes forms the basis of niche-specific asymmetric signaling and stem cell organization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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