IMMUNO-CORRECTING THERAPY AND INCREASED NITRATE EFFECTIVENESS IN ANGINA TREATMENT

Abstract

The justification of this study is the need for new methods (potentially, immuno-correcting therapy) of increasing nitrate effectiveness in complex angina treatment, reducing nitrate adverse effect incidence, and minimizing nitrate contraindications. It was suggested that angina-related endothelial dysfunction is related to impaired metabolism of NO, as one of the principal immune mediators. Nitrate therapy, acting via NO release, is aimed at endothelial function improvement. The study included 580 patients, in whom immune and cardiovascular status was assessed, together with nitrate tolerability and adverse effects. In 64% of the angina patients, clinical manifestations of immune insufficiency were observed, with monocyte-macrophage dysfunction as the major symptom. According to the results of ultrasound assessment of vaso-regulating endothelial function, more advanced endothelial dysfunction was registered in patients with reduced nitrate effectiveness. Immuno-correcting therapy was administered to 33 patients. After the treatment course, improved nitrate effectiveness was observed in all 33 individuals, in contrast to the control group (n=33).

Keywords

• angina
• endothelial dysfunction
• nitrates
• immuno-correction