Hypertrichosis: the possible side effect of cyclosporin in an infant with hemophagocyticlymphohistiocytosis receiving HLH-2004 chemotherapy protocol

Abstract

Hemophagocyticlymphohistiocytosis is a life-threatening condition of severe hyperinflammation that results from an uncontrolled proliferation of activated lymphocytes and histiocytes secreting high amounts of inflammatory cytokines. The immediate treatment strategies include immune suppressive therapy such as corticosteroid, etoposide and cyclosporin A. Herein, we present a 13-month-old infant who developed severe hypertrichosis after the administration of HLH-2004 treatment protocol. We discuss the various hypotheses regarding the causal relationship between cyclosporin A and hypertrichosis, emphasizing the importance of patient follow up.

Keywords

• Cyclosporin A
• hypertrichosis
• hemophagocyticlymphohistiocytosis
• corticosteroids