Beilstein Journal of Organic Chemistry (May 2018)

Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation

  • Mark Kelada,
  • John M. D. Walsh,
  • Robert W. Devine,
  • Patrick McArdle,
  • John C. Stephens

DOI
https://doi.org/10.3762/bjoc.14.104
Journal volume & issue
Vol. 14, no. 1
pp. 1222 – 1228

Abstract

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A simple one-pot method for the microwave-assisted synthesis of substituted pyrazolo[1,5-a]pyrimidinones, a core scaffold in many bioactive and pharmaceutically relevant compounds, has been established. A variety of substituents was tolerated at the 2 and 5 positions, including functionalized aryls, heterocycles, and alkyl groups.

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