Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus

Norzawani Buang; Lunnathaya Tapeng; Victor Gray; Alessandro Sardini; Chad Whilding; Liz Lightstone; Thomas D. Cairns; Matthew C. Pickering; Jacques Behmoaras; Guang Sheng Ling; Marina Botto

doi:10.1038/s41467-021-22312-y

Nature Communications (Mar 2021)

Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus

Norzawani Buang,
Lunnathaya Tapeng,
Victor Gray,
Alessandro Sardini,
Chad Whilding,
Liz Lightstone,
Thomas D. Cairns,
Matthew C. Pickering,
Jacques Behmoaras,
Guang Sheng Ling,
Marina Botto

Affiliations

Norzawani Buang: Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London
Lunnathaya Tapeng: Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London
Victor Gray: Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London
Alessandro Sardini: MRC London Institute of Medical Sciences, Imperial College London
Chad Whilding: MRC London Institute of Medical Sciences, Imperial College London
Liz Lightstone: Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London
Thomas D. Cairns: Imperial Lupus Centre, Imperial College Healthcare NHS Trust
Matthew C. Pickering: Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London
Jacques Behmoaras: Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London
Guang Sheng Ling: Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London
Marina Botto: Department of Immunology and Inflammation, Centre for Inflammatory Disease, Imperial College London

DOI: https://doi.org/10.1038/s41467-021-22312-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 15

Abstract

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Lupus pathogenesis is associated with high type 1 interferon stimulated gene (ISG) expression. Here, the authors correlate ISG expression in CD8+ T cells from lupus nephritis patients with abnormal mitochondrial function, implicating increased NAD consumption and reduced cell viability in the pathogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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