Clinical observation on the therapeutic efficacy of mesenchymal stem cell-derived exosomes for rosacea

Abstract

Objective To observe the therapeutic effects of mesenchymal stem cell-derived exosomes on rosacea. Methods Seventy-eight patients with rosacea, including 39 PPR type and 39 ETR type, were enrolled at the Changsha Mylike Cosmetic Hospital from January 2021 to January 2022. All patients were treated with microneedling infusion of mesenchymal stem cell-derived exosomes (MSC-exo) once a month for three months. The clinical efficacy, adverse reactions, erythema assessment scale (CEA), patient physical evaluation (PSA), investigators' global assessment (IGA) scale and skin barrier function were compared between the two groups. Results Treatment with MSC-exo significantly decreased both CEA and IGA scales, EI and TEWL, while increasing stratum corneum hydration (P<0.05 for all). After 3 treatments with MSC-exo, both CEA and IGA scales were higher in patients with ETR type than in that with PPR type (both P<0.05). Both EI and TEWL were lower in patients with PPR than in that with ETR (P<0.05). In contrast, both stratum corneum hydration levels and PSA were higher in patients with PPR than in that with ETR (P<0.05). The effective rates in patients with PPR type and ETR type were 89.74% and 64.10%, respectively (χ2=7.22, P=0.007). However, the adverse reaction rates were comparable between the two groups (χ2=1.92, P=0.166). Conclusions Treatments with MSC-exo can significantly improve the skin condition and skin barrier function in patients with rosacea. Compared with the ETR group, MSC-exo is more effective in improving skin condition in the PPR.

Keywords

• rosacea
• mesenchymal stem cell
• exosomes
• skin barrier
• microneedle