The mutREAD method detects mutational signatures from low quantities of cancer DNA

Juliane Perner; Sujath Abbas; Karol Nowicki-Osuch; Ginny Devonshire; Matthew D. Eldridge; Simon Tavaré; Rebecca C. Fitzgerald

doi:10.1038/s41467-020-16974-3

Nature Communications (Jun 2020)

The mutREAD method detects mutational signatures from low quantities of cancer DNA

Juliane Perner,
Sujath Abbas,
Karol Nowicki-Osuch,
Ginny Devonshire,
Matthew D. Eldridge,
Simon Tavaré,
Rebecca C. Fitzgerald

Affiliations

Juliane Perner: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre
Sujath Abbas: Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
Karol Nowicki-Osuch: Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge
Ginny Devonshire: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre
Matthew D. Eldridge: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre
Simon Tavaré: Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre
Rebecca C. Fitzgerald: Medical Research Council Cancer Unit, Hutchison/Medical Research Council Research Centre, University of Cambridge

DOI: https://doi.org/10.1038/s41467-020-16974-3
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 7

Abstract

Read online

Sequencing tumour genomes can reveal information about the processes that drive the formation of cancer. Here, the authors describe a method that can detect these mutational signatures from small amounts of DNA and degraded samples.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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